secobarbital will lower the extent or effect of aprepitant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.secobarbital will lessen the extent or effect of darifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.If you're taking much too much SEDATIVE-HYPNOTIC or overdose, call yo